Can I do M.Des after B.Tech but without 10+2?

Typically, a Master of Design M.Des programme requires a Bachelor's degree in a related field such as design, engineering, or architecture, and most universities also require a 10+2 or equivalent qualification for admission. However, admission requirements can vary by university and programme, so it

No, you cannot do any under graduate or post graduate course without 10+2 but if you had done Diploma and now you are doing B.Tech then you are eligible to do Masters.