Explain the role of allosteric site in enzyme inhibition?

This is a short answer type question as classified in NCERT Exemplar

Some drugs do not bind to the enzyme's active site. These bind to a different site of enzyme which is called allosteric site. This bonding of inhibitor at allosteric site changes the shape of the active site in such a way that substrate cannot recognise it. As a result, the affinity of the substrate for the active site is reduced.

It may be noted that if the bond formed between enzyme and inhibitor is strong covalent bond and therefore cannot be broken easily, then the enzyme gets blocked permanently. The body then degrades the enzyme inhibitor complex and synthesizes n

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This is a short answer type question as classified in NCERT Exemplar

Some drugs do not bind to the enzyme's active site. These bind to a different site of enzyme which is called allosteric site. This bonding of inhibitor at allosteric site changes the shape of the active site in such a way that substrate cannot recognise it. As a result, the affinity of the substrate for the active site is reduced.

It may be noted that if the bond formed between enzyme and inhibitor is strong covalent bond and therefore cannot be broken easily, then the enzyme gets blocked permanently. The body then degrades the enzyme inhibitor complex and synthesizes new enzyme.

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<p><span data-teams="true">This is a short answer type question as classified in NCERT Exemplar</span></p><p><span data-teams="true">Some drugs do not bind to the enzyme's active site. These bind to a different site of enzyme which is called allosteric site. This bonding of inhibitor at allosteric site changes the shape of the active site in such a way that substrate cannot recognise it. As a result, the affinity of the substrate for the active site is reduced.<br>&lt;!- [endif]-&gt;</span></p><div class="photo-widget-full"><div class="figure"><picture><source srcset="" media=" (max-width: 500px)"><img src="https://images.shiksha.com/mediadata/images/1750997535phpmSWhuD.jpeg" alt="" width="274" height="398" loading="lazy"></picture></div><div class="figure"><p>It may be noted that if the bond formed between enzyme and inhibitor is strong covalent bond and therefore cannot be broken easily, then the enzyme gets blocked permanently. The body then degrades the enzyme inhibitor complex and synthesizes new enzyme.</p></div></div>

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