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Yes, you can do fashion designing course after B.Com. , you can go for Masters programme such as M.Sc. (Design - Fashion), M. Design (Fashion). M.Sc. (Design - Fashion): The minimum eligibility criteria for M.Sc. , 50% aggregate marks in any Bachelors degree. A Masters of Science marks the completion of the first level of post-graduate study. Since these are some of the most competitive and the fastest-growing job markets in the world today, an increasing number of students are choosing to pursue a Masters degree to make themselves more professional. The field of fashion is roughly divided into two major categories: textiles and clothing design. There are Masters degrees available that offer a focus in both of these categories. An M.Sc. In Fashion teaches the basics of making and marketing beautiful clothes, as well as the very important business side of the fashion industry. Fashion is a highly competitive industry, and one of the benefits of earning a Masters is that it lets hiring managers know that the degree holder is knowledgeable and serious about the field. During the course of studying for a Masters, students also have access to high-quality materials and equipment so they can get the feel for a wide variety of techniques. M. Design (Fashion): The Master of Design programme is 2 years (4 semesters) duration intensive professional programme. The minimum eligibility criteria for M. Design, 50% aggregate marks in any Bachelors degree. This course focus on imparting design thinking skills and research capability to provide solutions to problems through design, the programme will enable graduates to work in all kinds of design related services. Top colleges for Fashion Design Programme:
BIT Ranchi
NSIT, New Delhi
Lovely Professional University, Jalandhar
Symbiosis Institute of Design (SID), Pune
College of Engineering, Pune
Faculty of Engineering & Technology, Jamia Millia Islamia.

Firstly, try to think about the courses based on your interest, and ask yourself that you can able to do your desired course. Basically, present time required the skilled person and try to do professional course. There is a huge variety of course available in India after class 12th Science. It would be highly recommended and most ideal, if you try to pursue your education in a field of your liking and interest. Also, practical/work based industries are the most 'in' thing to go for as they guarantee placements as the course is more practical oriented. These course include Hotel Management, Sound Engineering, Bio-Technology, amongst others. Hope I was able to be of some help to you.