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There is no absolute best course after 12th for future. This is because future jobs require more skills than a theoretical knowledge of the subject. So, any course that helps you to learn more and more industry-specific skills is considered to be the more futuristic course.

For this reason, engineering courses like Computer Science, IT and Civil remain on the top as these courses teach not just theoretical concepts but also require students to learn several tools and digital applications to carry out major applications and operations. Since some of these tools or alike have a direct industry connection, graduates from these courses remain in demand by top employers.  

Other high salary courses after 12th for future include a bachelor's degree in a chosen field (e.g., Engineering, Medicine, Arts, Commerce, Science), vocational or technical courses, skills-specific Diploma programs, professional certifications (project management, product management, data science, graphic design, digital marketing, Python, My SQL, etc.), entrepreneurship and leadership. 

Remember, a top course can only get you to meet with the top employers but securing a job with a good package still requires you to crack that interview and prove to the employers that you have all the knowledge about all the software, theoretical concepts and tools that will be needed to do this job. 

There are many high salary courses available for girls after 12th Science. Here are some top options, along with potential career paths and average salary ranges:

1. Engineering (B.Tech/B.E.):
   • Popular Specialisations: Computer Science, AI/ML, Data Science and Electronics
   • Careers: Software Engineer, Data Scientist and AI Engineer
   • Salary Range: ?4,00,000 - ?25,00,000+ per annum
2. Medicine (MBBS):
   • Careers: Doctor, Surgeon and Specialists
   • Salary Range: ?5,00,000 - ?30,00,000+ per annum
3. Biotechnology:
   • Careers: Biotechnologist, Research Scientist and Biomedical Engineer
   • Salary Range: ?3,00,000 - ?15,00,000+ per annum
4. Pharmacy (B.Pharm):
   • Careers: Pharmacist, Drug Developer and Clinical Research Associate
   • Salary Range: ?3,00,000 - ?12,00,000+ per annum
5. Architecture (B.Arch):
   • Careers: Architect, Urban Planner and Interior Designer
   • Salary Range: ?3,00,000 - ?20,00,000+ per annum
6. Chartered Accountancy (CA):
   • Careers: Chartered Accountant, Financial Analyst and Investment Banker
   • Salary Range: ?5,00,000 - ?25,00,000+ per annum
7. Actuarial Science:
   • Careers: Actuary, Risk Analyst and Insurance Underwriter
   • Salary Range: ?4,00,000 - ?20,00,000+ per annum
8. Pilot Training:
   • Careers: Commercial Pilot and Flight Instructor
   • Salary Range: ?10,00,000 - ?50,00,000+ per annum
9. Data Science and Analytics:
   • Careers: Data Scientist, Business Analyst and Machine Learning Engineer
   • Salary Range: ?5,00,000 - ?25,00,000+ per annum
10. Law (integrated after 12th):
    • Careers: Corporate Lawyer, Legal Consultant and Judge
    • Salary Range: ?4,00,000 - ?30,00,000+ per annum

According to some reports, many girls and women are recorded to be engaged and working in the STEM fields due to several factors such as inadequate exposure to Science and technology, limited access to role models and mentors, and a lack of confidence in their own abilities. However, there are various opportunities and fields where women remain in high demand and may have high earning potential. These fields include medicine, engineering (preferably computer Science engineering and IT), data science, artificial intelligence and machine learning.

Apart from the above degrees, girls can also boost their career/make their career by optimising skills like communication, problem-solving, collaboration and teamwork, leadership, knowledge of specific scientific software such as Matlab, AutoCAD, or GIS, data analysis and visualisation, programming and scientific computing.

Determining the single "the highest scope" course after 12th Science with PCM is difficult because "scope" can encompass various aspects. Below is a breakdown of some high-demand fields to consider, keeping in mind your interests and goals:

• Engineering: Engineering disciplines like Computer Science, Mechanical Engineering, Electrical Engineering, and Civil Engineering will likely have consistent demand due to their application in various industries and ongoing technological advancements.
• Data Science/Machine Learning: This field bridges computer science, statistics, and mathematics, offering exciting opportunities in artificial intelligence, big data analysis, and technological innovation. The demand for skilled professionals is high, leading to good scope.
• Biotechnology/Biomedical Sciences: These fields combine life sciences with engineering principles, with applications in pharmaceuticals, medical research, and healthcare. The ageing population and focus on personalised medicine create a promising scope for these specialisations.
• BSc (Hons) in Business Administration (BBA) with a specialization: A business degree with a specialisation in finance or marketing can equip you for high-paying careers in banking, investment banking, or marketing management. The business landscape is constantly evolving, offering good scope for growth.

Choosing what to do after 12th Science can be exciting and overwhelming. Here's a simplified guide:

• Self-discovery comes first. Reflect on what truly interests and excites you. What subjects did you enjoy? What are your natural strengths and values? Knowing yourself paves the way for a fulfilling career.
• Explore your options! Consider higher education in fields like engineering, medicine, or data science. Explore vocational training paths like pilot training or nursing. If you have the spark, entrepreneurship might be your calling.
• Do your research. Talk to professionals in fields you're curious about. Explore salary trends and university websites. Gather as much information as possible to make an informed decision.