What is present in the liver by which ammonia converts it into urea?
Asked by PURUSOTTAM ROUT
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3 Answers
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Ammonia is converted to urea in the liver via urea cycle. this cycle takes place in the mitochondria of the hepatic cells. For further references check Lehninger's Principles of Biochemistry by Nelson and Cox.
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The conversion of ammonia to urea takes place in liver and to some extent in kidney also known as urea cycleIt is a step by step process catalysed by various enzymes at each stepL-ornithinecarbamoyl phosphate
L-citrulline
argininosuccinate
fumarate
L-arginine
L-Asp L-aspartate
CPS-1 carbamoyl phosphate synthetase I
OTC Ornithine transcarbamoylase
ASS argininosuccinate synthetase
ASL argininosuccinate lyase
ARG1 arginase 1
To study the details of urea cycle you can refer any book book of biochemistry -
Ammonia is a toxic by-product of protein metabolism and is generally converted to less toxic substances after it is produced then excreted; mammals convert ammonia to urea. Urea is simpler in structure and less harmful for the body. Ammonia is an extremely toxic base and its accumulation in the body would quickly be fatal.
However, the liver contains a system of carrier molecules and enzymes which quickly converts the ammonia (and carbon dioxide) into urea.
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