What is the syllabus for M.Sc in Biotechnology at Fergusson College?

For First year, Semester 1 Topics under Molecular biology: 1 Genome Structure and organisation Definition and organisation of viral, prokaryotic and eukaryotic genomes: Structure of chromatin, nucleosome, chromatin organisation and remodeling, higher order organisation- chromosome, centromere, telomere. Histones and their effect on structure and function of chromatin. C value paradox and genome size, Cot curves, repetitive and non-repetitive DNA sequences, satellite DNA, DNA melting and buoyant density. Gene families, clusters, Pseudogenes, super-families, Organelle genomes 2 Mobile DNA elements Transposable elements in bacteria, IS elements, composite transposons, replicative and non-replicative transposons, Mu transposition, p-elements, Controlling elements in TnA and Tamil Nadu 10 transposition. SINES and LINES, retrotransposons 3 DNA damage and Repair Types of DNA damage, DNA repair mechanisms- nucleotide excision repair, base excision repair, mismatch repair, recombination repair, double strand break repair, transcriptional coupled repair 4 Recombination Homologous and site-specific recombination, models for homologous recombination- Holiday junction, NHEJ Proteins involved in recombination- RecA, RuvA, B, C, Gene conversion 5 DNA Replication and Regulation DNA polymerases and mechanisms of DNA replication in prokaryotes and eukaryotes DNA replication models, connection of replication to cell cycle, Gene amplification (rRNA) Reverse Transcriptase 6 Gene Expression and Regulation in Prokaryotes and Eukaryotes Transcription: Basic mechanism in prokaryotes and eukaryotes. RNA Polymerases, pseudo-ORFs Chromatin remodeling in relation to gene expression, DNase hypersensitivity, DNA methylation. Regulation of transcription including transcription factors. Post-transcriptional processing and transport of RNA. Non coding RNAs, organisation and structure-function of ribonucleoproteins (Ribonome concept). 7 Protein Synthesis and Regulation Components of protein synthesis, Mechanism of protein synthesis, Genetic code, codon usage, Regulation of protein synthesis.

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